VEGF E (Orf Virus)

VEGF-E (Orf Virus) is a unique viral-encoded vascular endothelial growth factor homolog that selectively binds and activates VEGFR-2 (KDR/Flk-1), a receptor primarily responsible for angiogenesis and endothelial cell proliferation. Derived from the Orf virus, VEGF-E mimics the function of mammalian VEGF but with enhanced receptor specificity and minimal binding to VEGFR-1. This selective activation leads to potent angiogenic responses without the inflammatory effects typically associated with VEGFR-1 activation. VEGF-E is a valuable tool in vascular biology research, tumor angiogenesis studies, and therapeutic angiogenesis applications, offering insights into endothelial signaling pathways and potential strategies for vascular regeneration. - 1mg