ELISA Recombinant Keratin, type II cuticular Hb5(KRT85)

Quantity:100µg. Other Quantitys are also available. For further information, please contact us. Research Areas:Others Uniprot ID:P78386 Gene Names:KRT85 Organism:Homo sapiens () AA Sequence:MSCRSYRISSGCGVTRNFSSCSAVAPKTGNRCCISAAPYRGVSCYRGLTGFGSRSLCNLGSCGPRIAVGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKWQFYQNQRCCESNLEPLFSGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVVLKKDVDCAYLRKSDLEANVEALVEESSFLRRLYEEEIRVLQAHISDTSVIVKMDNSRDLNMDCIIAEIKAQYDDVASRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEIENAKCQRAKLEAAVAEAEQQGEAALSDARCKLAELEGALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEHRLCEGVGSVNVCVSSSRGGVSCGGLSYSTTPGRQITSGPSAIGGSITVVAPDSCAPCQPRSSSFSCGSSRSVRFA Expression Region:1-507aa Sequence Info:FµLl Length Source:Yeast Tag Info:N-terminal 6xHis-tagged MW:57.1 kDa Alternative Name(s):Hair keratin K2.12 (Keratin-85) (K85) (Type II hair keratin Hb5) (Type-II keratin Kb25) (KRTHB5) Relevance: Reference:"SPRR1 gene induction and barrier formation occur as coordinated moving fronts in terminally differentiating epithelia." Marshall D., Hardman M.J., Byrne C. J. Invest. Dermatol. 114:967-975(2000) Purity:Greater than 85% as determined by SDS-PAGE. Form:Liquid or Lyophilized powder Buffer:If the delivery form is liquid, the defaµLt storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Function: Involvement in disease:Ectodermal dysplasia 4, hair/nail type (ECTD4) SubcellµLar Location: Protein Families:Intermediate filament family Tissue Specificity:Synthesis occurs immediately above a small popµLation of matrix cells at the base of the hair bµLb and the trichocytes lining the dermal papilla and extends upward throµgh the matrix and ends in the lower part of the cortex of the hair shaft. Paythway: HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:6462 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=182507 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:3891 STRING Database Link:https://string-db.org/network/9606.ENSP00000257901 OMIM Database Link:https://www.omim.org/entry/602032602032602032 Lead Time Guidance:25-35 business days