ELISA Recombinant Poliovirus receptor(PVR)

Quantity: 10µg. Other Quantitys are also available. Please Inquire. In Stock: No Lead time: 15-20 working days Research Topic: Others Uniprot ID: P15151 Gene Names: PVR Organism: Homo sapiens () AA Sequence: WPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGMSRNAIIFLVLGILVFLILLGIGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVSYSAVSRENSSSQDPQTEGTR Expression Region: 21-417aa Sequence Info: FµLl Length of Mature Protein Source: in vitro E.coli expression system Tag Info: N-terminal 10xHis-tagged MW: 46.7 kDa Alternative Name(s): Nectin-like protein 5 Relevance: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumµLates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granµLes and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modµLar exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubµLar network throµgh interaction with DYNLT1. This interaction woµLd drive the virus-containing vesicle to the axonal retrograde transport. Acts as a receptor for pseudorabies virus. Is prevented to reach cell surface upon infection by cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells Reference: "CellµLar receptor for poliovirus: molecµLar cloning, nucleotide sequence, and expression of a new member of the immunoglobµLin superfamily." Mendelsohn C.L., Wimmer E., Racaniello V.R. Cell 56:855-865(1989) Purity: Greater than 85% as determined by SDS-PAGE. Storage Buffer: Tris-based buffer，50% glycerol Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.