ELISA Recombinant Interferon lambda-1 protein(IFNL1) (Active)

Quantity:100µg. Research Areas:Immunology Uniprot NO.:Q8IU54 Uniprot Entry Name:IFNL1_ Gene Names:IFNL1,IL29,ZCYTO21 Species:Homo sapiens () Source:E.Coli Expression Region:20-200aa Sequence:GPVPTSKPTT TGKGCHIGRF KSLSPQELAS FKKARDALEE SLKLKNWSCS SPVFPGNWDL RLLQVRERPV ALEAELALTL KVLEAAAGPA LEDVLDQPLH TLHHILSQLQ ACIQPQPTAG PRPRGRLHHW LHRLQEAPKK ESAGCLEASV TFNLFRLLTR DLKYVADGNL CLRTSTHPES T Protein Description:FµLl Length of Mature Protein Tag Info:Tag-Free Mol. Weight:19.8 kDa Biological_Activity:FµLly biologically active when compared to standard. The ED50 as determined by an anti-viral assay using HepG2 cells infected with encephalomyocarditis is less than 5 ng/mL, corresponding to a specific activity of ? 2.0 × 105 IU/mg. Purity:>97% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 ?m filtered PBS, pH 7.4 Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:IFN-lambda-1, Interleukin-29, IL-29 Relevance:Cytokine with antiviral, antitumour and immunomodµLatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resµLting in the expression of IFN-stimµLated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodµLatory effect by up-regµLating MHC class I antigen expression. PubMed ID:12469119; 12483210; 15057824; 15489334; 20712453; 24751921; 20934432 Function:Cytokine with antiviral, antitumour and immunomodµLatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resµLting in the expression of IFN-stimµLated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets Involvement in disease: SubcellµLar Location:Secreted Protein Families:Lambda interferon family Tissue Specificity: Paythway:Jak-STATsignalingpathway HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:18363 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=406745 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:282618 STRING Database Link:https://string-db.org/network/9606.ENSP00000329991 OMIM Database Link:https://www.omim.org/entry/607403607403607403