ELISA Recombinant Lymphotoxin-alpha protein(LTA) (Active)

Quantity:100µg. Research Areas:Signal Transduction Uniprot NO.:P01374 Uniprot Entry Name:TNFB_ Gene Names:LTA,TNFB,TNFSF1 Species:Homo sapiens () Source:E.Coli Expression Region:35-205aa Sequence:LPGVGLTPSA AQTARQHPKM HLAHSTLKPA AHLIGDPSKQ NSLLWRANTD RAFLQDGFSL SNNSLLVPTS GIYFVYSQVV FSGKAYSPKA TSSPLYLAHE VQLFSSQYPF HVPLLSSQKM VYPGLQEPWL HSMYHGAAFQ LTQGDQLSTH TDGIPHLVLS PSTVFFGAFA L Protein Description:FµLl Length of Mature Protein Tag Info:Tag-Free Mol. Weight:18.7 kDa Biological_Activity:FµLly biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 5 pg/mL, corresponding to a specific activity of ? 2.0 × 108 IU/mg in the presence of actinomycin D. Purity:>96% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 µm filtered PBS, pH7.4, with 0.02 % Tween-20 Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:LT-alpha, Tumor necrosis factor ligand superfamily member 1 Relevance:Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. PubMed ID:3555974; 3001109; 3536896; 6334807; 1353024; 8499947; 10202016; 14656967; 15489334; 1451807; 1733919; 8387891; 1670638; 1671667; 12746914; 17353895 Function:Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. Involvement in disease:Psoriatic arthritis (PSORAS) SubcellµLar Location:Secreted, Membrane Protein Families:Tumor necrosis factor family Tissue Specificity: Paythway:NF-kappaBsignalingpathway HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:6709 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=36 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:4049 STRING Database Link:https://string-db.org/network/9606.ENSP00000403495 OMIM Database Link:https://www.omim.org/entry/153440153440153440