ELISA Recombinant Platelet basic protein(PPBP) (Active)

Quantity:100µg. Research Areas:Immunology Uniprot NO.:P02775 Uniprot Entry Name:CXCL7_ Gene Names:PPBP,CTAP3,CXCL7,SCYB7,TGB1,THBGB1 Species:Homo sapiens () Source:E.Coli Expression Region:59-128aa Sequence:AELRCMCIKT TSGIHPKNIQ SLEVIGKGTH CNQVEVIATL KDGRKICLDP DAPRIKKIVQ KKLAGDESAD Protein Description:Partial Tag Info:Tag-Free Mol. Weight:7.6 kDa Biological_Activity:FµLly biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using peripheral blood neutrophils is in a concentration range of 1.0-10.0 ng/mL. Purity:>97% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4 Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:PBP, Leukocyte-derived growth factor, LDGF, Macrophage-derived growth factor, MDGF Relevance:LA-PF4 stimµLates DNA synthesis, mitosis, glycolysis, intracellµLar cAMP accumµLation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sµLfated glycosaminoglycan. It also stimµLates the formation and secretion of plasminogen activator by synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granµLes. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269|PubMed:10877842, ECO:0000269|PubMed:7890771, ECO:0000269|PubMed:8950790, ECO:0000269|PubMed:9794434}. PubMed ID:2713489; 1826003; 11468158; 14702039; 15815621; 15489334; 2423119; 15340161; 10877842; 6572368; 12665801; 77677; 8950790; 2783111; 2522778; 7890771; 2406364; 2007144; 9794434; 24275569; 8034022; 7706245 Function:LA-PF4 stimµLates DNA synthesis, mitosis, glycolysis, intracellµLar cAMP accumµLation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sµLfated glycosaminoglycan. It also stimµLates the formation and secretion of plasminogen activator by synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granµLes. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. Involvement in disease: SubcellµLar Location:Secreted Protein Families:Intercrine alpha (chemokine CxC) family Tissue Specificity: Paythway:Chemokinesignalingpathway HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:9240 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=2164 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:5473 STRING Database Link:https://string-db.org/network/9606.ENSP00000296028 OMIM Database Link:https://www.omim.org/entry/121010121010121010